Use Your Gut Microbiome to Lose Weight

The gut microbiome can have a significant effect on our health. From immunity to mood and metabolism – it can even help us lose weight. However, there is a lot of misinformation about our gut microbes and weight loss out there, and we like hard evidence. Here, we are going to give you a down-to-the-nitty-gritty overview of the link between our beloved gut microbes and weight loss.

The gut microbiota is made up of trillions of bacteria, forming an ecosystem that interacts with the human body. It is involved in many critical functions such as immunity, metabolism and digestion1. However, when the microbes are out of sync, also known as dysbiosis, you might be in trouble. A decrease in beneficial bacteria, or an increase in pathogens can affect the body’s homeostasis – a fancy term for having a well-balanced microbiota. This, in turn, can affect your weight. Although bacteria will not make you skinny or fat, they can help regulate nutrient absorption, metabolism and gut health. Scientists are working hard on discovering which bacteria, in particular, are involved in weight regulation. Currently, two bacteria have well-established links to weight loss. Let’s meet them, shall we?

Akkermansia muciniphila – a mucus-loving bug

If you are a GUTXY blog reader, you will be well aware that we’ve already mentioned this beneficial microbe before. If you’re new here, let’s recap! A. muciniphila is a bacterium that feeds off the lining of the gut, stimulating its production and enhancing the barrier between the gut and the rest of the body. It converts mucus constituents into short-chain fatty acids (SCFAs,) such as acetates that then regulate appetite and fat storage 2. Studies show that A. muciniphila is inversely associated with obesity3 and that probiotic supplementation with A. muciniphila improves metabolic health 4.

You could boost your A. muciniphila abundance with probiotics or by including foods like walnuts, chili peppers, cranberries, grapes and flaxseeds5,6,7.

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Christensenella minuta – the new kid on the block

Christiensenella minuta is a newer bacterial species, discovered in 2012. Its function in the human gut is not yet fully understood, but some research points towards protein and fibre fermentation 8. Since the discovery of Ch. minuta, researchers have found that it has a strong hereditary influence, meaning that its abundance might be passed on genetically. Studies show that it is significantly more abundant in lean people with a low body mass index9, and it is significantly less common in pre-diabetic patients 10. Researchers from Cornell University, together with a King’s College team, discovered that, when mice with a microbiota transferred from an obese person, had additional Ch. minuta added, they actually gained less weight compared to Ch. minuta free mice.

To boost your Ch. mintua abundance, make sure to add legumes¹¹ to your diet, as well as foods rich in Resveratrol, such as red grapes, cranberries, strawberries and blueberries. Also, stay away from refined sugars¹².

If you would like to see whether your weight management struggle is related to the lack of these two bacteria, try RESET+. With exclusive new technology, unseen anywhere else, RESET+ is our tailored gut wellness program that uses your microbes as a marker of how diet changes affect your gut and thus, your health.


  1. Bellet al., (2015) Changes seen in gut bacteria content and distribution with obesity: causation or association? Postgraduate Medicine, 127:8, 863-868.
  2. Chambers et al., (2018) Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Current Nutrition Reports 7,198–206.
  3. Van Hul & Cani (2019) Targeting Carbohydrates and Polyphenols for a Healthy Microbiome and Healthy Weight. Curr Nutr Rep 8, 307–316
  4. Dao et al., (2016) Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut 65(3), 426-36.
  5. Anhê, F et al., (2014). A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansiaspp. population in the gut microbiota of mice. Gut, 64(6), 872-883.
  6. Roopchand, D. et al., (2015). Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphila and Attenuate High-Fat Diet–Induced Metabolic Syndrome. Diabetes, 64(8), 2847-2858.
  7. Kajla, P., et al., (2015). Flaxseed-a potential functional food source. Journal of food science and technology52(4), 1857–1871.
  8. Waters et al., (2019). The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health. BMC Biol 17(83).
  9. Goodrich et al., (2014). Human genetics shape the gut microbiome. Cell, 159(4), 789-99.
  10. Org et al., (2017). Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biol. 18 (70).
  11. Azcarate-Peril et al., (2017). Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proc Natl Acad Sci U S A. 114(3), E367-E375
  12. Waters et al., (2019). The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health. BMC Biol 17(83).
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