What is the Importance of Faecalibacterium prausnitzii in Human Health & Disease?

Faecalibacterium prausnitzii is important for keeping our gut healthy. It does this by helping to reduce inflammation and supporting the gut barrier. 

Faecalibacterium prausnitzii is a helpful bacterium found in the human gut. It plays an important role in maintaining a healthy gut. Here are a few reasons why: 

  • Reduces inflammation: Faecalibacterium prausnitzii produces a substance called butyrate which helps reduce inflammation in the gut. This can help prevent inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.1
  • Protects against harmful substances: Faecalibacterium prausnitzii helps maintain the gut barrier which protects against harmful substances and pathogens. This can reduce the risk of inflammation and related diseases. 1,2
  • Associated with health benefits: Higher levels of Faecalibacterium prausnitzii in the gut have been linked to improved metabolic health, better weight management and reduced risk of certain diseases like obesity, type 2 diabetes and cardiovascular disease. 3
  • Linked to certain diseases: When the balance of Faecalibacterium prausnitzii is disrupted it can contribute to certain gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome.2 Reduced levels of Faecalibacterium prausnitzii in the gut have also been linked to obesity, metabolic syndrome, insulin resistance and other metabolic disorders.4

To reduce the risk of disease, it’s important to maintain a healthy balance of Faecalibacterium prausnitzii and other beneficial bacteria in the gut.


  1. Dikeocha, I. J., Al-Kabsi, A. M., Chiu, H.-T., & Alshawsh, M. A. (2022). Faecalibacterium prausnitzii Ameliorates Colorectal Tumorigenesis and Suppresses Proliferation of HCT116 Colorectal Cancer Cells. Biomedicines, 10(5).
  2. Martín, R., Rios-Covian, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez-Humarán, L. G., Sokol, H., Chatel, J.-M., & Langella, P. (2023). Faecalibacterium: A bacterial genus with promising human health applications. FEMS Microbiology Reviews, 47(4), fuad039.
  3. Faecalibacterium prausnitzii Improves Lipid Metabolism Disorder and Insulin Resistance in Type 2 Diabetic Mice—PMC. (n.d.). Retrieved 23 April 2024, from
  4. Kallassy, J., Gagnon, E., Rosenberg, D., Silbart, L. K., & McManus, S. A. (2023). Strains of Faecalibacterium prausnitzii and its extracts reduce blood glucose levels, percent HbA1c, and improve glucose tolerance without causing hypoglycemic side effects in diabetic and prediabetic mice. BMJ Open Diabetes Research & Care, 11(3), e003101.

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