Probiotics are generally considered safe for most people, but some individuals may experience side effects when taking too many probiotics. The potential side effects associated with probiotics vary depending on the specific strain, and the intensity of side effects could be correlated with the intake of probiotic dosage.
Some strains may lead to increased bloating, flatulence, and loose stools, while others like Saccharomyces boulardii may cause constipation and potential systemic infections such as sepsis. However, these systemic infections are uncommon in healthy individuals, often occurring in people with immunosuppressive conditions or those undergoing antibiotic therapy, which can exacerbate symptoms.
In most cases, side effects subside with continued use of probiotics past the initial influx of short-chain fatty acids arising from excessive probiotic use¹.