What are Refrigerated Probiotics?

Since probiotics contain live strains of bacteria, some probiotics may degrade when subjected to heat stress¹. Refrigerated probiotics are thus probiotics that need to be refrigerated in order to preserve their integrity. Different strains of probiotics have varying tolerances to heat and should be stored at specific temperatures to maintain their efficacy. To determine whether a probiotic needs to be refrigerated, consult the manufacturer labels for the product.


  1. Song, J., Xiao, K., Ke, Y. L., Jiao, L. F., Hu, C. H., Diao, Q. Y., Shi, B., & Zou, X. T. (2014). Effect of a probiotic mixture on intestinal microflora, morphology, and barrier integrity of broilers subjected to heat stress. Poultry Science, 93(3), 581–588.

On this page